Patholoay of the mouse, 1999, cache river press, vienna, il. Development of the laboratory mouse began with pet fanciers who bred mice for their unique coat colors. For the rat, laboratory strains still harbor a large portion of the haplotypes present in wild isolates, suggesting a relatively recent common origin and supporting the idea that rat inbred strains, in contrast to mouse inbred strains. A volume in the laboratory animal pocke reference series.
Intravenous injection tail vein mouse revised may 2016 1 laboratory animal biomethodology workshop u the laboratory mouse intravenous injection tail vein 1. Guidelines for tissue collection for genotyping mice and rats purpose the correct genetic identification of geneticallymodified rodents is critical to the efficiency and reproducibility of research and for. Scissors should be sharpened or replaced at appropriate intervals based on use. Een waardevol naslagwerk voor gebruikers van laboratorium muizen. Short communication whole blood is the sample matrix of choice for monitoring systemic triclocarban levels nils helge schebba, ki chang ahnb,1, hua dongb, shirley j.
The laboratory mouse is a small mammal of the order rodentia which is bred and used for scientific research. For medical laboratory technology students health laboratory management and quality assurance endris mekonnen university of gondar in collaboration with the ethiopia public health training initiative, the carter center, the ethiopia ministry of health, and the ethiopia ministry of education 2004. He is currently the interim president of the european college of laboratory animal medicine eclam and an honorary member of the american college of laboratory animal medicine aclam. Perhaps because mice live in such close proximity with humans and. Anintroductionandguidetosuccessfullyimplementingalims laboratoryinformationmanagementsystem bentagger computersciencedepartment universityofwales,aberystwyth. Laboratory mouse, second edition is a comprehensive book written by international experts. Klebsiella species charles river research animal diagnostic. Fresh blood from swiss webster mice was spiked with 100 nm tcc and incubated at 37 c.
The laboratory mouse was derived from the common house mouse, mus musculus. In the past 25 years, genetically engineered mice gem and rats ger have advanced from novelty status to essential tools in biomedical research programs. Whole blood is the sample matrix of choice for monitoring. Mouse genome informatics the jackson laboratory bar harbor, maine april 2005 revised. From a scientific perspective, physically and mentally healthy animals also contribute to increased validity and reproducibility of experimental results. Laboratory mouse the laboratory mouse is a small mammal. Laboratory mouse the laboratory mouse is a small mammal of. Hair on the back is clipped by a cordless electric clipper. Laboratory animals centre carshalton, surrey, england academic press 1965 adapted for the web by. Read guide for the care and use of laboratory animals. Due to its ability to colonize a wide range of species, klebsiella can be readily transmitted from one species to another, including from humans to animals and vice versa. The laboratory mouse handbook of experimental animals hedrich hans, hans hedrich among animals used in research, teaching and testing, mice are now widely recognized as the most important model for human diseases and disorders. Featuring newly revised european standards on laboratory animals, this book is the uptodate authority on the care of.
Comfortable quarters for laboratory animals by animal welfare institute isbn 9780938414797 lcn 2015947590 tenth edition, 2015 printed in the united states edited by cathy liss, kenneth litwak, dave tilford, and viktor reinhardt design by ava rinehart and alexandra alberg references to internet websites urls were accurate at the time of. Brown university institutional animal care and use committee rodent genotyping policy page 2 of 4. Applied information technology for the laboratory pdf. Alternatively, hot bead sterilizers or newly sterilized equipment for each. If you need to print pages from this book, we recommend downloading it as a pdf. Her own view of her situation might be very different. Nevertheless, it was not until clarence cook little developed the first inbred mouse strain, dba, in 1909 that the modern laboratory mouse was born. The ufaw handbook on the care and management of laboratory and other research animals, eighth edition. Download here if searching for a ebook the laboratory mouse handbook of experimental animals in pdf form, then you have come on to the loyal site. Lab math solutions, dilutions, concentrations and molarity. Iclas manual for genetic monitoring of inbred mice. The goal of this study was to gain insight into the effects of myostatin inhibition, using a chronic genetic deletion mouse model, on multiple organ systems in the setting of aging. Environmental enrichment of rodents introduction a major objective of the nih animal care and use program is to promote the humane care and use of animals in biomedical research and this guidance serves as a set of best practices to help achieve that goal. Guidelines for tissue collection for genotyping mice and rats purpose the correct genetic identification of geneticallymodified rodents is critical to the efficiency and reproducibility of research and for reducing the number of animals involved in a research project.
The anatomy of the laboratory mouse mgimouse genome. This is a free sample of content from manipulating the mouse embryo. Unfortunately, this book cant be printed from the openbook. Systemic approach to evaluation of mouse mutations.
In part, this is due to the longstanding genetic resources available for the mouse, but now also the development of powerful new techniques for generation of mutations, analysis of complex traits, and high throughput data gathering, have made the mouse the preeminent model for the study of human. Additionally the laboratory mouse continues to play a widely publicized vital role in the human genome project. However, mouse enrichment has proven to be very complex due to the. Guidelines for tissue collection for genotyping mice and rats. The two lateral tail veins are small vessels on each side of the tail, directly under. Jul 28, 2018 the laboratory mouse is still considered behaviorally similar to wild mice in many dimensions 1 p150, though it differs somewhat from the wild. Broome rl, feng l, zhou q, smith a, hahn n, matsui sm, omary mb.
Entering and exiting the gcis mouse facility entering the facility, suite, and preparing the hood 1. Alternatively, hot bead sterilizers or newly sterilized equipment for each animal can be used. Download pdf ebooks and manuals free the laboratory mouse. Hedrich is a professor at hannover medical school in germany. For more information please contact centers for disease control and prevention 1600 clifton road ne, atlanta, ga 30333 telephone, 1 800cdcinfo 232 4636tty. A laboratory manual, fourth edition mouse hematology. Modis mouse disease information system is implemented on a microsoft access database microsoft corp. The genetic identity mirrors the degree of consanguinity obtained by crossing littermates over 20 generations hedrich, 2004. The tcc blood and plasma levels 4 h after oral gavage. The laboratory mouse handbook of experimental animals 2nd edition, kindle edition. Institutional animal care and use committee iacuc rodent.
During the course the book principles of laboratory animal science, revised edition, 2001, l. With inclusions of the newly revised european standards on laboratory animals, this will be the most. Maybe she thinks the man is trapped in an unhappy relationship with a spiteful or weak woman. A simple technique minimizing the distress on the animals. Laboratory mouse housing conditions can be improved using. The laboratory mouse hedrich hj ed biotechnische vereniging. Applied information technology for the laboratory pdf,, download ebookee alternative practical tips for a much. Swipe your chicago card university of chicago id through the reader to enter the mouse facility. Manipulating the mouse embryo cold spring harbor laboratory. Effects of myostatin deletion in aging mice morissette. One of the most timeconsuming activities in research laboratories is looking up information specific to the species or strain of animal being used. Rodent genetics, models, and genotyping methods springerlink. Mice inhabit most parts of the world where humans live.
Download laboratory mouse stock photos at the best stock photography agency with millions of premium high quality, royaltyfree stock photos, images and pictures at reasonable prices by hans hedrich. The mouse disease information system modis is a data capture system for pathology data from laboratory mice designed to support phenotyping studies. Internet and print resources to facilitate pathology. These fancy mice then became subjects for research due to interest in the mechanisms of inheritance of these coat colors. The choice of nesting material or shelter type, referred to as environmental enrichment, may influence how laboratory animals perform species. Substance solutions should be isotonic same tonicity as blood. Infection of skin scratches and bite wounds with mouse or humanborne opportunistic microbes demands attention through a strict occupational medical treatment program national research council, 1997. The hated rival browning does not show directly what the woman for whom the poison is intended is like.
Jul 30, 2012 the laboratory mouse, second edition is a comprehensive book written by international experts. Twocolor, userfriendly format combined with color plate sections. Over 10 million scientific documents at your fingertips. Download laboratory mouse stock photos at the best stock photography agency with millions of premium high quality, royaltyfree stock photos, images and pictures at reasonable prices by hans hedrich, gillian bullock, peter petrusz july 2012 the laboratory mouse, second edition is a comprehensive book written by international experts. The tail is held using the palm and forefinger and then the left hind leg is fixed between the ring and little finger when the mouse is. Due to its ability to colonize a wide range of species. From a scientific perspective, physically and mentally healthy animals also contribute to increased validity. He is currently the interim president of the european college of laboratory animal medicine eclam and an honorary member. If you or someone at your laboratory is willing to participate, please contact mary giknis through charles river laboratories, 251 ballardvale street, wilmington, ma 01887. Interleukin10 il10 is an important suppressor of immune responses in vitro studies indicate that il10 directly inhibits il2 and il5 production by th1 and th2 cells. The laboratory mouse, second edition is a comprehensive book written by international experts. Laboratory mice mus musculus and rats rattus norvegicusare the most commonly used animals in biomedical and. Featuring newly revised european standards on laboratory animals, this book is the uptodate authority on the care of mice in laboratory research internationally. By 1901, william castle, the greatgrandfather of mammalian genetics, recognized the potential of mice to test mendels theories.
Integrating mouse anatomy and pathology ontologies into a. With inclusions of the newly revised european standards on laboratory animals, this will be the most current, global authority on the care of mice in laboratory research. For the rat, laboratory strains still harbor a large portion of the haplotypes present in wild isolates, suggesting a relatively recent. A laboratory manual, fourth edition click here for more information or to buy the book.
The laboratory mouse has long been the species of choice for many animal models of human diseases. We present full edition of this ebook in epub, txt, doc, djvu, pdf. Author summary adequate housing of laboratory animals is essential to guarantee their wellbeing. The laboratory mouse, 2e is a comprehensive book written by international experts. Impact of heparin and short term anesthesia on the. Infection of skin scratches and bite wounds with mouse or human. You are advised to consult the publishers version publishers pdf if. Put on a hairnet, face mask, disposable lab coat, and a pair of shoe covers. Mouse genome informatics the jackson laboratory bar harbor, maine april 2005 revised february 2008 table of contents subject index image index users guide. University of groningen efficient single nucleotide.
The guide for the care and use of laboratory animals nrc, 2011, hereafter. Internet and print resources to facilitate pathology analysis. Anintroductionandguidetosuccessfullyimplementingalims. Historical foundations muriel t davisson and carol c linder 1 5 introduction 1 5 historical foundations 1 5 history of mouse genetics and research with the laboratory. The laboratory mouse handbook of experimental animals. Adequate housing of laboratory animals is essential to guarantee. The provision of environmental enrichment to numerous species of laboratory animals is generally considered routine husbandry. Davis, and currently use a tail vein catheter for more than 95% of our mouse intravenous injections.
546 547 684 1510 795 846 1145 1438 1489 195 1475 416 500 1108 1448 494 1357 1429 135 8 1180 747 31 975 1438 331 1475 360 1342 474 1219 422